This article by Multiple Sclerosis Today discusses the importance of regular MRIs for people with MS even when in remission. “Silent inflammation” and “smoldering lesions” can cause damage to the CNS without exhibiting outward symptoms. Chronic inflammation from MS causes lesions or scarring on the CNS, which can interfere with signal conduction. Silent inflammation occurs in the background and is often caused by underlying conditions. Smoldering lesions are a more aggressive course of MS and are identified by dark, expanding rims around their light centers. Regular MRIs help identify smoldering lesions, allowing for more targeted therapies to prevent further damage.